Methyldopa

Methyldopa or alpha-methyldopa (brand names Aldomet, Apo-Methyldopa, Dopamet, Novomedopa) is a centrally-acting adrenergic antihypertensive medication. Its use is now deprecated following introduction of alternative safer classes of agents. However it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (formerly known as pregnancy-induced hypertension).

Side effects

There are many reported side-effects, which range from mild to serious. Nevertheless, side effects are generally mild when the dose is less than 1 g per day:[2]Gastro-intestinal disturbancesDry mouthBradycardia (slow pulse rate)Worsening of anginaOrthostatic hypotension (Postural hypotension)Sedation, headaches, dizzinessMyalgia (muscle pain), arthralgia (joint pain) or paraesthesia (numbness)Nightmares, mild psychosis, depressionParkinsonismBell's palsyAbnormal liver functions tests and hepatitisPancreatitisHaemolytic anaemiaBone marrow suppression leading to thrombocytopenia (low platelets) or leucopenia (low white blood cells)Hypersensitivity reactions including lupus erythematosus-like syndrome, myocarditis (heart muscle inflammation), pericarditis and rashesEjaculatory failure, Impotence, decreased libido, gynecomastia (breast enlargement in men), hyperprolactinaemia and amenorrhoeaUp to 20% may become Coombs test positive, which may complicate antenatal serology blood tests.May also cause lichenoid reactions